« Late » est une forme de démence tout juste découverte. © Kateryna_Kon, Fotolia

This newly discovered form of dementia is very common among older people.

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In 2019, neuroscientists at the University of Kentucky in the United States discovered a form of dementia called “Late” (for Limbic-predominant age-related TDP-43 encephalopathy). the symptom are close to those of Alzheimer diseasebut its origin is different and an unknown. An accumulation of an abnormal way of protein functions
Proteins can perform a wide variety of functions within the cell or organism.
They may have:
a structural function (such as actin or tubulin that…” data-image=”https://cdn.futura-sciences.com/buildsv6/images/midioriginal/4/6/e/46e94f9da7_50034188_actin-thomas-splettstoesser – cc.jpg” data-url=”https://news.google.com/health/definitions/biology-protein-237/” data-more=”Read More”>protein TDP-43 within the cytoplasm of cells in neurons is one of the markers of the disease. The treatments prescribed to treat Alzheimer’s disease are ineffective in the context of Late.

A large clinical study has been launched to estimate the There are various types of…” data-image=”https://cdn.futura-sciences.com/buildsv6/images/midioriginal/4/5/7/4575b9b026_53969_prevalence. jpg” data-url=”https://news.google.com/sante/definitions/medicine-prevalence-2818/” data-more=”Read more”>predominance of this disease in the population. In progress, provides its first results : approximately 40% of the elderly present this form of dementiaand more than 50% in those who already have Alzheimer’s disease.

40% of the patients studied have this form of dementia

About 6,000 brains, in the form of biopsyof data genetic and clinical, were analyzed for this investigation. The participants were on average 88 years old and came from all over the world. Post-autopsy, 39.4% of the patients were affected by Late, regardless of stage; and 54.9% in those who also had Alzheimer’s-type senile plaques. ” Since older ages are when dementia is more common, Late’s results are particularly important. Although there are many differences between the studies combined here, from design to methodologies, they reveal the importance of Late and suggest that our findings will be relevant beyond any one country or region of the world. », Carol Brayne saidprofessor of public health at Cambridge University and member of the research team.

The researchers now wish to continue their research with Historically, a Roman legion had ten cohorts numbered I through X. © Peter Bernik, Shutterstock
cohort study
A study of…” data-image=”https://cdn.futura-sciences.com/buildsv6/images/midioriginal/9/e/4/9e4667b473_98839_cohort.jpg” data-url=”https://news .google.com/health/definitions/medicine-cohort-15863/” data-more=”Read more”>cohorts more diverse, including people of Asian and African origin, to verify that certain populations are not more predisposed to the disease.

A new form of dementia that resembles Alzheimer’s

article of Celine Deluzarchepublished on May 3, 2019

Researchers have just discovered a new form of dementia called “Late” whose symptoms are very similar to those of Alzheimer’s disease but involve a different mechanism. A possible explanation for the failure of all the treatments tried so far to cure the disease.

Many falsely diagnosed Alzheimer’s patients may actually be suffering from a new form of dementia called “Late,” according to an international meta-study published April 30, 2019 in the journal Brain. This disease is widespread, affecting more than 25% of people over 85 years of age. The researchers thus estimate that its impact would be “ as important as Alzheimer’s in elderly patients.

The TDP-43 protein in question

Late’s symptoms are similar to those of Alzheimer’s, with a memory loss progressively progressing to impairment of all daily activities. However, its evolution would be slower and, above all, its mechanism would be completely different: while Alzheimer’s disease is linked to accumulation of amyloid plaques and tau protein in brain function
Located in the braincase, the brain is the seat of higher functions (cognitive functions, senses, nerve responses) and vegetative functions. It is therefore an essential organ that regulates everything…” data-image=”https://cdn.futura-sciences.com/buildsv6/images/midioriginal/5/c/b/5cb474dd85_121782_cerveau-3d .jpg” data- url=”https://news.google.com/health/definitions/biology-brain-3125/” data-more=”Read more”>brain, Late involves the protein TDP-43 which appears in an abnormal structure during the disease. On the other hand, touch the same parts of the brainwhich extends first to the amygdala and then to the hippocampus, plays a key role in the process of long-term memory storage and…” data-image=”https://cdn. future-sciences.com/buildsv6 /images/midioriginal/e/9/3/e93f683f8d_127038_hippocampus-fish.jpg” data-url=”https://news.google.com/planete/definitions/zoology-hippocampus-4673/” data-more=”Read more”>Sea Horse and finally, to the convolution frontal medium.

A prevalence 100 times higher than other forms of dementia

According to Health: what is the WHO?
As stated in its constitution, the WHO aims to bring all people to the highest level of health…” data-image=”https://cdn.futura-sciences.com/buildsv6/images/midioriginal/ c/0/3 /c0318e9153_101519_oms-logo.jpg” data-url=”https://news.google.com/sante/definitions/medecine-oms-4321/” data-more=”Read more”>WHO, 60% to 70% of dementia cases are attributable to Alzheimer’s disease. But according to Peter Nelson, a professor at the University of Kentucky Sanders-Brown Center and lead author of the study, we tend to associate all dementias too quickly with Alzheimer’s. ” There are more than 200 kinds of virus coldsemphasizes the doctor, Why should there be only one cause of dementia? ? “.

Some other degenerative diseases are already well known, such as It begins with disorders…” data-url=”https://news.google.com/sante/definitions/medecine-Maladie-creutzfeldt-jakob-4169/” data -more =”Read more”>Creutzfeldt-Jakob diseasefrontotemporal dementia (FTD) due to cerebral atrophy or dementia due to lewy body. The late form is thought to be much more common, with a prevalence 100 times higher than FTD, the researchers report.

Definitive diagnosis possible only post-mortem

It must be said that the diagnosis dementia, which is defined as a neurological disease characterized by a progressive deterioration of cognitive abilities, is very difficult to establish. The symptoms vary greatly from one individual to another, some lose their memory, for example, others language or orientation.

the disease breaks out more or less early, some being affected after the age of 40, others after the age of 80. the diagnosis Definitive can only be established post-mortem for an Autopsy Purpose
The purpose of an autopsy is to accurately determine the causes of death of a victim. They are also practiced by medical students to learn human anatomy.
Deployment of a…” data-image=”https://cdn.futura-sciences.com/buildsv6/images/midioriginal/e/e/f/eefcf89d2f_50036516_autopsie-ralf-wiki-gfdl.jpg” data-url = “https://news.google.com/health/definitions/medicine-autopsy-8999/” data-more=”Read more”>autopsy of the brain, doctors rely solely on symptomatic criteria to reach their conclusion.

Finally, the concomitance of neurodegenerative diseases with other age-related problems and their more or less rapid progression complicate matters. Brain’s study also indicates that the coexistence of Late and Alzheimer’s is relatively common, with, in this case, accelerated cognitive decline.

99.6% failure of Alzheimer’s treatments

This discovery raises hope and new questions. A hope, because it could explain the monumental failure of therapies against Alzheimer’s tried so far: 99.6% of clinic tests conducted between 2002 and 2012 failed by review counts Nature.

However, many patients who were recruited for these clinical trials could have been affected by Late, meaning that the potentially favorable results for Alzheimer’s disease would have been “diluted” by unaffected patients. But this does not solve the underlying problem, which is the difficulty in establishing an adequate diagnosis.

Even if we discover an effective drug against Late, how do we know who to prescribe it to? Therefore, the researchers call for a more precise study of the immunological biomarkers dementia, detectable when the person is still alive.

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